Hyperenterostatinemia in premenopausal obese women.

نویسندگان

  • C Prasad
  • M Imamura
  • C Debata
  • F Svec
  • N Sumar
  • J Hermon-Taylor
چکیده

Enterostatins [Val-Pro-Asp-Pro-Arg (VPDPR), Val-Pro-Gly-Pro-Arg (VPGPR), and Ala-Pro-Gly-Pro-Arg (APGPR)] are pentapeptides derived from the NH2-terminus of procolipase after tryptic cleavage and belong to the family of gut-brain peptides. Although enterostatin-like immunoreactivities exist in blood, brain, and gut, and exogenous enterostatins decrease fat appetite and insulin secretion in rats, the roles of these peptides in human obesity remain to be examined. To determine whether VPDPR and APGPR secretion is altered in obesity, serum VPDPR and APGPR levels were measured in 38 overnight-fasted subjects (body mass index, 17.9-54.7 kg/m2) before and after a meal. The mean fasting VPDPR in the serum of lean subjects was significantly lower than that in obese subjects [lean = 603 +/- 86 nmol/L (n = 17); obese, 1516 +/- 227 nmol/L (n = 21); P = 0.0023]. In addition, the rise in serum APGPR after a meal (postmeal/fasting ratio) was significantly higher in lean than in obese subjects [lean, 1.71 +/- 0.24 (n = 17); obese, 1.05 +/- 0.14 (n = 21); P = 0.0332]. The results of these studies show hyperenterostatinemia in obesity and a diminution in enterostatin secretion after satiety.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

To Study the Relationship between Obesity and Anti-Mullerian Hormone: As a Serum Marker of Ovarian Reserve In premenopausal Women

This study was performed with an objective to study the relationship between obesity and AMH as a serum marker of ovarian reserve in premenopausal women. We performed a cross-sectional comparative study of two agematched groups of late premenopausal participants: 50 participants (“non-obese”) had a BMI < 30 kg/m 2 , and the other 50 participants (“obese”) had a BMI of 30 to 35 kg/m 2 .The obese...

متن کامل

Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women

Background and Objectives:Previous studies have demonstrated that adipokines can have positive and/or negative effects on vascular function. In this study, we attempted to characterize the association of adipokines with endothelium-dependent vasodilation in healthy premenopausal women. Subjects and Methods:Noninvasive pulse wave analysis coupled with provocative pharmacological testing with sal...

متن کامل

Oxidative and inflammatory status and HDL functions of obese pre and post menopausal women

Objectıve: Obesity and age related vascular changes coupled with the effect of estrogen withdrawal increases predisposition to atherosclerosis in postmenopausal women. But the functions of high density lipoprotein (HDL) were not well established in postmenopausal women. In the present study, we mainly aimed to evaluate the changes in the functions of HDL and aimed to measure, lipid peroxidation...

متن کامل

Diminished adrenal sensitivity and ACTH efficacy in obese premenopausal women.

BACKGROUND The ACTH-cortisol axis in women is activated and associated with decreased ACTH potency, estimated by relating ACTH and cortisol pulse masses. Recently, a new accurate method for constructing the endogenous dose-response relationship was introduced, which is based on the relation between ACTH concentrations and associated cortisol secretion rates within cortisol bursts. HYPOTHESIS ...

متن کامل

Breast cancer is associated to impaired glucose/insulin homeostasis in premenopausal obese/overweight patients

The association between breast cancer (BCa) presence and altered glucose/insulin metabolism is controversial likely due to an inaccurate insulin resistance (IR) assessment and inappropriate stratification of patients by body-mass index (BMI) and menopausal state. 148 women with suspect of sporadic BCa were stratified by BMI and menopause. Fasting levels of glucose, insulin, glycohemoglobin and ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • The Journal of clinical endocrinology and metabolism

دوره 84 3  شماره 

صفحات  -

تاریخ انتشار 1999